06-P038 Great vessel development requires dizygous expression of Chd7 and Tbx1 in pharyngeal ectoderm
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چکیده
06-P038 Great vessel development requires dizygous expression of Chd7 and Tbx1 in pharyngeal ectoderm Karen McCue, Victoria Randall, Catherine Roberts, Vanessa Kyriakopoulou, Francesca Vitelli, Katrina Prescott, Koen Devriendt, Charles Shaw-Smith, Subreena Simrick, M. Albert Basson, Elizabeth Illingworth, Peter Scambler Molecular Medicine Unit Institute of Child Heath, London, United Kingdom Texas A& M Health Science Center, Houston, United States Center for Human Genetics, Catholic University of Leuven, Leuven, Belgium Wellcome Trust Sanger Institute, Hinxton, United Kingdom Department of Craniofacial Development, King’s College London, London, United Kingdom Dulbecco Telethon Institute, Naples, Italy Department of Chemistry, Universita degli Studi di Salerno, Fisciano, Italy
منابع مشابه
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06-P038 Great vessel development requires dizygous expression of Chd7 and Tbx1 in pharyngeal ectoderm Karen McCue, Victoria Randall, Catherine Roberts, Vanessa Kyriakopoulou, Francesca Vitelli, Katrina Prescott, Koen Devriendt, Charles Shaw-Smith, Subreena Simrick, M. Albert Basson, Elizabeth Illingworth, Peter Scambler Molecular Medicine Unit Institute of Child Heath, London, United Kingdom Te...
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06-P038 Great vessel development requires dizygous expression of Chd7 and Tbx1 in pharyngeal ectoderm Karen McCue, Victoria Randall, Catherine Roberts, Vanessa Kyriakopoulou, Francesca Vitelli, Katrina Prescott, Koen Devriendt, Charles Shaw-Smith, Subreena Simrick, M. Albert Basson, Elizabeth Illingworth, Peter Scambler Molecular Medicine Unit Institute of Child Heath, London, United Kingdom Te...
متن کاملGreat vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice.
Aortic arch artery patterning defects account for approximately 20% of congenital cardiovascular malformations and are observed frequently in velocardiofacial syndrome (VCFS). In the current study, we screened for chromosome rearrangements in patients suspected of VCFS, but who lacked a 22q11 deletion or TBX1 mutation. One individual displayed hemizygous CHD7, which encodes a chromodomain prote...
متن کاملTbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development.
During embryonic life, the initially paired pharyngeal arch arteries (PAAs) follow a precisely orchestrated program of persistence and regression that leads to the formation of the mature aortic arch and great vessels. When this program fails, specific cardiovascular defects arise that may be life threatening or mild, according to the identity of the affected artery. Fourth PAA-derived cardiova...
متن کاملTbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm.
Elucidating the gene regulatory networks that govern pharyngeal arch artery (PAA) development is an important goal, as such knowledge can help to identify new genes involved in cardiovascular disease. The transcription factor Tbx1 plays a vital role in PAA development and is a major contributor to cardiovascular disease associated with DiGeorge syndrome. In this report, we used various genetic ...
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009